These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.

 

RESEARCH

  • Liu W et al.Development of a neuroprotective potential algorithm for medicinal plants. University of Rhode Island. Neurochem Int. 29 Sep 2016. 100: 164-177. - As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.


  • Nam DE et al. Effect of Boswellia serrata extract [WokVel®] on degenerative OA in invitro and  in vivo models.  J Korean Soc Food Sci Nutr. 2014 Apr 2. 43(5). DOI: http://dx.doi.org/10.3746/jkfn.2014.43.5.페이지 - WokVel® Extract mediated articular cartilage degeneration by preventing extracellular matrix degradation and chondrocyte injury. It significantly reduced and normalized the production of pro-inflammatory biomarkers and also significantly reduced 5-LOX activity and production of PEG2. Researchers indicated that, “one can consider that [WokVel®] extract may be a potential therapeutic treatment for degenerative [OA].”


  • REVIEW: Ernst E. Frankincense: Systematic review. BMJ. 2008 Dec 18. 337: a2813. DOI: 10.1136/bmj.a2813 - Summary and review of various clinical trials on Boswellia serrata with mentions of WokVel® clinicals included.


  • Sontakke S et al. Open, randomized, controlled clinical trial of Boswellia serrata extract  [WokVel®] as compared to valdecoxib in OA of knee. Indian J Pharmacol. 2007 Feb. Vol 39(Issue 1): 27-29. - Efficacy, safety, and tolerability of WokVel was compared with an NSAID in 66 patients for six months. WokVel exhibited a slower onset; however, persisted even after discontinued supplementation, whereas the action of the NSAID became evident faster but quickly dissipated after stopping treatment.


  • Sharma S et al. Pharmacokinetic study of 11-keto β-boswellic acid. Phytomedicine. 2004 Feb. 11: 255-260. - A single 333mg dose of WokVel® was found to lead to plasma concentrations of 11-keto-boswellic acid (KBA) shown to address the pro-inflammatory cytokine 5-lipoxygenase. WokVel® was safe and well tolerated.


  • Kimmatkar N et al. Efficacy and tolerability of Boswellia serrata extract [WokVel®] in treatment  of OA of knee – A randomized double blind placebo controlled trial. Phytomedicine. 2003. 10: 3-7.  - In this study, 30 subjects were administered either WokVel® or placebo for eight weeks. After a washout period following the first intervention, the groups were crossed to receive the opposite treatment for eight weeks. All subjects that received WokVel® reported decreased knee pain, increased knee flexion, and increased walking distance. The observed differences between WokVel and placebo were reported as statistically significant and clinically relevant. 

 

WOKVEL SLP RESEARCH

  • Gota P et al. Comparison of the Metabolic Stability of Solid Lipid Boswellia Serrata  Particles Versus Plain Boswellia Serrata Extract in Human Hepatocytes (HHL-17). Int J Pharm Chem Biol Sci. 2016. 6(1): 22-27. - In an in vitro study in human hepatocytes HHL-17, WokVel® SLP™ (Solid Lipid Particle) exhibited lesser accumulation of KBA in hepatocytes and low metabolic clearance. With reported extremely low hepatic clearance of AKBA and conferred metabolic stability of KBA in this study, WokVel® SLP™ may have enhanced oral bioavailability of KBA and AKBA compared to WokVel.


  • Gota P et al. Efficacy of solid lipid Boswellia serrata particles (SLBSP) in OA of knee.  J Pharm Sci Tech Mgmt. Vol 1(Issue 2) 2015 Jul. 70-76.