DaSilva N et al. Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid™] seed oil. University of Rhode Island: INBRE Poster Presentation. 2017. - Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.
- Licari M et al. J Nutri Food Sci. 2019 Mar 06. Vol 9(No 2): 751. doi: 10.4172/2155-9600.1000751 - The results of this study found that a high fat diet increased blood pressure and fasting blood glucose compared to control. Further the high fat diet group given black cumin seed oil, saw a reduction in blood pressure and fasting blood glucose compared to those fed a high ft diet alone; offering support for the use of thymoquinone to support metabolic health.
- Gray JP et al. Am J Physiol Endocrinol Metab. 2016 Mar 15. 310(6): E394-404. ePub 2016 Jan 19. doi: 10.1152/ajpendo.00250.2015 - Recently published in-vitro study supports that Nigella sativa extracts standardized to thymoquinone normalize glucose-stimulated insulin secretion (GSIS) from pancreatic b-cells by enhancing the sensitivity of b-cells metabolic pathways to glucose and GSIS under normal conditions as well as under hyperglycemia.
- Fallah HH et al. Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944 - A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.
- Chaieb K et al. BCM Comp Alter Med. 2011. 11(1): 29. - Thymoquinone from Nigella sativa exhibited antibacterial effects and promoted antimicrobial properties in vitro.
- Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L seed. Int Immunopharmacol. 2005. 5(13): 1749-1770.