These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.


  • DaSilva N et al. Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid®] seed oil. University of Rhode Island: INBRE Poster Presentation. 2017. - Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.



  • Licari M et al. Beneficial effects of thymoquinone on metabolic function and fatty liver in  a murine model of obesity. J Nutri Food Sci. 2019 Mar 06. 9(2): 751. doi: 10.4172/2155-9600.1000751 The results of this study found that a high fat diet increased blood pressure and fasting blood glucose compared to control. Further the high fat diet group given black cumin seed oil, saw a reduction in blood pressure and fasting blood glucose compared to those fed a high ft diet alone; offering support for the use of thymoquinone to support metabolic health.

  • Gray JP et al. Thymoquinone, a bioactive component of Nigella sativa , normalizes insulin  secretion from pancreatic β-cells under glucose overload via regulation of  malonyl-CoA. Am J Physiol Endocrinol Metab. 2016 Mar 15. 310(6): E394-404. EPub 2016 Jan 19. doi: 10.1152/ajpendo.00250.2015 Recently published in-vitro study supports that Nigella sativa extracts standardized to thymoquinone normalize glucose-stimulated insulin secretion (GSIS) from pancreatic b-cells by enhancing the sensitivity of b-cells metabolic pathways to glucose and GSIS under normal conditions as well as under hyperglycemia.

  • Namazi N et al. Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie  diet in obese women: A randomized, double-blind controlled trial.  Phytother Res. 29(11): 1722-1728. Obese women received a low-calorie diet with Nigella sativa (NS) oil (3 g/day) or a placebo for 8 weeks. Results showed that the NS oil concurrent with a low calorie diet decreased weight (-4.80 +/- 1.50 kg) and increased SOD in obese women compared to placebo.

  • Mahdavi R et al. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk  factors in obese women: A randomized controlled clinical trial. Food Funct. 2015. 6(6): 2041-2048. Obese women received a low-calorie diet with Nigella sativa (NS) and it was found that in the NS group, weight, weight circumference, triglycerides, and very low density lipoprotein levels all decreased significantly compared to the placebo group. Weight even decreased by 6%, and waist circumference by 6.9%.

  • Yuan T et al. Indazole-Type alkaloids from Nigella sativa seeds exhibit antihyperglycemic  effects via AMPK activation in vitro. J Nat Prod. 2014 Oct 09. 77(10): 2316-2320. doi: 10.1021/np500398m A naturally occurring alkaloid from the N. sativa seed increased glucose consumption by liver hepatocytes through activation of AMP-activated protein kinase (AMPK). This is also the first report of 4-O-methylnigellidine and 4-O-methylnigeglanine from a natural source.

  • Fallah HH et al. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy  volunteers: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944 - A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.

  • Sabzghabaee AM et al. Clinical evaluation of Nigella sativa seeds for the treatment of  hyperlipidemia: A randomized, placebo controlled clinical trial. Med Arch. 2012. 66(3): 198-200. Patients in the study group took 2 grams of N. sativa per day for 4 weeks. A significant decrease in total cholesterol, low density lipoprotein, and triglyceride levels was seen, and it was concluded that N. sativa may have some beneficial effects in promoting healthy blood lipid levels.

  • Gheita TA et al. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis  patients: A placebo controlled study. Phytother Res. 2012. 26(8): 1246-1248. doi: 10.1002/ptr.3679 - Female patients took a placebo for a month and then NS oil for the month after, 1 gram a day. The activity scores significantly decreased compared with before and after NS oil supplementation, as well as the number of swollen joints and the duration of morning stiffness.

  • Yang W et al. Effect of thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse  dendritic cells. Cell Physiol Biochem. 2012. 29(1-2): 21-30. doi: 10.1159/000337583 Thymoquinone, a component of Nigella sativa, has shown anti-inflammatory effects and compromises the function of dendritic cells. This study shows that this action might be due to an innate inhibition of the sodium hydrogen exchanger by thymoquinone.

  • Mohtashami R et al. Blood glucose lowering effects of Nigella sativa L seeds oil in healthy human  volunteers: A randomized, double-bind, placebo-controlled clinical trial. J Med Plants. 2011. 3(39): 90-94. 70 healthy subjects were split into two groups; the study group took 5mL of Nigella sativa oil per day and the control group took 5mL mineral oil per day, both for two months. It was concluded that the administration of NS oil in this way resulted in beneficial effects on glycemic profile (fasting blood glucose, HbA1c, liver and renal function) without any adverse effects.

  • Chaieb K et al. Antibacterial activity of thymoquinone, and active principle of Nigella sativa  and its potency to prevent bacterial biofilm formation. BCM Comp Alter Med. 2011. 11(1): 29. - Thymoquinone from Nigella sativa exhibited antibacterial effects and promoted antimicrobial properties in vitro.

  • Nikakhlagh S et al. Herbal treatment of allergic rhinitis: The use of Nigella sativa. Am J Otolaryngol. 2011. 32(5): 402-407. doi: 10.1016/j.amjoto.2010.07.019 - A placebo-controlled study (n = 66) found that N. sativa should be considered for treating allergic rhinitis as a viable alternative to current medication.

  • Datau EA et al. Efficacy of Nigella sativa on serum free testosterone and metabolic  disturbances in central obese male. Acta Med Indones. 2010 Jul. 42(3). 130-134. - A double blind, randomized, placebo-controlled study with obese males (aged 30 – 45 years) found that there was a significant reduction in body weight, waist circumference, and systolic blood pressure in the treatment group. Nigella sativa was also found to possibly inhibit the decreasing of serum free testosterone.

  • Namji A et al. Effect of Nigella sativa oil on various clinical and biochemical parameters of  insulin resistance syndrome. Int J Diab Dev Ctries. 2008 Jan-Mar. 28(1): 11-14. doi: 10.4103/0973-3930.41980 A prospective study testing the effect of N. sativa oil as an add-on therapy in patients of insulin resistance syndrome. Indeed, the oil was found to have significant improvement in total cholesterol, low density lipoprotein cholesterol, and fasting blood glucose.



  • Amin B et al. Review: Black cumin (Nigella sativa) and its active constituent, thymoquinone:  An overview on the analgesic and anti-inflammatory effects. Planta Med. 2016 Jan. 82(1-2): 8-16. EPub 2015 Sep 14. doi: 10.1055/s-0035-1557838 A review going into detail on all the properties of black cumin and thymoquinone; mainly focused on antinociceptive and anti-inflammatory effects.

  • Darakhshan S et al. Review: Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015. 95(96): 138-158. doi: 10.1016/j.phrs.2015.03.011 A review focused specifically on the actions of thymoquinone, the active constituent of Nigella sativa. The pharmacological actions of thymoquinone include, but are not limited to, antioxidant, anti-inflammatory, immunomodulatory, and anti-microbial.

  • Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L seed. Int Immunopharmacol. 2005. 5(13): 1749-1770. - A review that focuses on both Nigella (NS) oil and thymoquinone (TQ); Discusses the various effects and properties that NS oil and TQ possess.