These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.


RESEARCH

  • DaSilva N et al. Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid™] seed oil. University of Rhode Island: INBRE Poster Presentation. 2017. - Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.

 

SUPPORTIVE RESEARCH

  • Licari M et al. Beneficial effects of thymoquinone on metabolic function and fatty liver in  a murine model of obesity. J Nutri Food Sci. 2019 Mar 06. Vol 9(No 2): 751. doi: 10.4172/2155-9600.1000751 The results of this study found that a high fat diet increased blood pressure and fasting blood glucose compared to control. Further the high fat diet group given black cumin seed oil, saw a reduction in blood pressure and fasting blood glucose compared to those fed a high ft diet alone; offering support for the use of thymoquinone to support metabolic health.

  • Gray JP et al. Thymoquinone, a bioactive component of Nigella sativa , normalizes insulin  secretion from pancreatic β-cells under glucose overload via regulation of  malonyl-CoA. Am J Physiol Endocrinol Metab. 2016 Mar 15. 310(6): E394-404. ePub 2016 Jan 19. doi: 10.1152/ajpendo.00250.2015 Recently published in-vitro study supports that Nigella sativa extracts standardized to thymoquinone normalize glucose-stimulated insulin secretion (GSIS) from pancreatic b-cells by enhancing the sensitivity of b-cells metabolic pathways to glucose and GSIS under normal conditions as well as under hyperglycemia.

  • Namazi N et al. Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie  diet in obese women: A randomized, double-blind controlled trial.  Phytother Res. 29(11): 1722-1728.

  • Mahdavi R et al. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk  factors in obese women: A randomized controlled clinical trial. Food Funct. 2015. 6(6): 2041-2048.

  • Yuan T et al. Indazole-Type alkaloids from Nigella sativa seeds exhibit antihyperglycemic  effects via AMPK activation in vitro. J Nat Prod. 2014 Oct 09. 77(10): 2316-2320. doi: 10.1021/np500398m

  • Fallah HH et al. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy  volunteers: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944 - A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.

  • Sabzghabaee AM et al. Clinical evaluation of Nigella sativa seeds for the treatment of  hyperlipidemia: A randomized, placebo controlled clinical trial. Med Arch. 2012. 66(3): 198-200.

  • Gheita TA et al. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis  patients: A placebo controlled study. Phytother Res. 2012. 26(8): 1246-1248. doi: 10.1002/ptr.3679

  • Yang W et al. Effect of thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse  dendritic cells. Cell Physiol Biochem. 2012. 29(1-2): 21-30. doi: 10.1159/000337583

  • Mohtashami R et al. Blood glucose lowering effects of Nigella sativa L seeds oil in healthy human  volunteers: A randomized, double-bind, placebo-controlled clinical trial. J Med Plants. 2011. 3(39): 90-94.

  • Chaieb K et al. Antibacterial activity of thymoquinone, and active principle of Nigella sativa  and its potency to prevent bacterial biofilm formation. BCM Comp Alter Med. 2011. 11(1): 29. - Thymoquinone from Nigella sativa exhibited antibacterial effects and promoted antimicrobial properties in vitro.

  • Nikakhlagh S et al. Herbal treatment of allergic rhinitis: The use of Nigella sativa. Am J Otolaryngol. 2011. 32(5): 402-407. doi: 10.1016/j.amjoto.2010.07.019

  • Datau EA et al. Efficacy of Nigella sativa on serum free testosterone and metabolic  disturbances in central obese male. Acta Med Indones. 2010 Jul. 42(3). 130-134.

  • Namji A et al. Effect of Nigella sativa oil on various clinical and biochemical parameters of  insulin resistance syndrome. Int J Diab Dev Ctries. 2008 Jan-Mar. 28(1): 11-14. doi: 10.4103/0973-3930.41980

 

REVIEWS

  • Amin B et al. Review: Black cumin (Nigella sativa) and its active constituent, thymoquinone:  An overview on the analgesic and anti-inflammatory effects. Planta Med. 2016 Jan. 82(1-2): 8-16. EPub 2015 Sep 14. doi: 10.1055/s-0035-1557838

  • Darakhshan S et al. Review: Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015. 95(96): 138-158. doi: 10.1016/j.phrs.2015.03.011

  • Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L seed. Int Immunopharmacol. 2005. 5(13): 1749-1770.