DaSilva N et al. Anti-melanogenic potential of thymoquinone isolated from black cumin (Nigella sativa L) [as Thymocid™] seed oil. University of Rhode Island: INBRE Poster Presentation. 2017. - Tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 plays a major role in melanin synthesis. Supports youthful skin by inhibiting Tyrosinase and melanin production to look skin tone more even. In an in vitro study, TQ’s de-pigmenting ability against B16F10 melanoma cells was not caused by direct inhibition of the tyrosinase enzyme, but by inhibition of tyrosinase processing and maturation in the melanoma cells. This effect is associated with TQ’s ability to down regulate gene and protein expressions of MITF, TYRP-1 and TYRP-2.
- Licari M et al. J Nutri Food Sci. 2019 Mar 06. 9(2): 751. doi: 10.4172/2155-9600.1000751 - The results of this study found that a high fat diet increased blood pressure and fasting blood glucose compared to control. Further the high fat diet group given black cumin seed oil, saw a reduction in blood pressure and fasting blood glucose compared to those fed a high ft diet alone; offering support for the use of thymoquinone to support metabolic health.
- Gray JP et al. Am J Physiol Endocrinol Metab. 2016 Mar 15. 310(6): E394-404. EPub 2016 Jan 19. doi: 10.1152/ajpendo.00250.2015 - Recently published in-vitro study supports that Nigella sativa extracts standardized to thymoquinone normalize glucose-stimulated insulin secretion (GSIS) from pancreatic b-cells by enhancing the sensitivity of b-cells metabolic pathways to glucose and GSIS under normal conditions as well as under hyperglycemia.
- Namazi N et al. Phytother Res. 29(11): 1722-1728. - Obese women received a low-calorie diet with Nigella sativa (NS) oil (3 g/day) or a placebo for 8 weeks. Results showed that the NS oil concurrent with a low calorie diet decreased weight (-4.80 +/- 1.50 kg) and increased SOD in obese women compared to placebo.
- Mahdavi R et al. Food Funct. 2015. 6(6): 2041-2048. - Obese women received a low-calorie diet with Nigella sativa (NS) and it was found that in the NS group, weight, weight circumference, triglycerides, and very low density lipoprotein levels all decreased significantly compared to the placebo group. Weight even decreased by 6%, and waist circumference by 6.9%.
- Yuan T et al. J Nat Prod. 2014 Oct 09. 77(10): 2316-2320. doi: 10.1021/np500398m - A naturally occurring alkaloid from the N. sativa seed increased glucose consumption by liver hepatocytes through activation of AMP-activated protein kinase (AMPK). This is also the first report of 4-O-methylnigellidine and 4-O-methylnigeglanine from a natural source.
- Fallah HH et al. Phytother Res. 2013. 27(12): 1849-1853. doi: 10.1002/ptr.4944 - A randomized, double-blind, placebo controlled trial (n=70) found Nigella oil improved blood pressure.
- Sabzghabaee AM et al. Med Arch. 2012. 66(3): 198-200. - Patients in the study group took 2 grams of N. sativa per day for 4 weeks. A significant decrease in total cholesterol, low density lipoprotein, and triglyceride levels was seen, and it was concluded that N. sativa may have some beneficial effects in promoting healthy blood lipid levels.
- Gheita TA et al. Phytother Res. 2012. 26(8): 1246-1248. doi: 10.1002/ptr.3679 - Female patients took a placebo for a month and then NS oil for the month after, 1 gram a day. The activity scores significantly decreased compared with before and after NS oil supplementation, as well as the number of swollen joints and the duration of morning stiffness.
- Yang W et al. Cell Physiol Biochem. 2012. 29(1-2): 21-30. doi: 10.1159/000337583 - Thymoquinone, a component of Nigella sativa, has shown anti-inflammatory effects and compromises the function of dendritic cells. This study shows that this action might be due to an innate inhibition of the sodium hydrogen exchanger by thymoquinone.
- Mohtashami R et al. J Med Plants. 2011. 3(39): 90-94. - 70 healthy subjects were split into two groups; the study group took 5mL of Nigella sativa oil per day and the control group took 5mL mineral oil per day, both for two months. It was concluded that the administration of NS oil in this way resulted in beneficial effects on glycemic profile (fasting blood glucose, HbA1c, liver and renal function) without any adverse effects.
- Chaieb K et al. BCM Comp Alter Med. 2011. 11(1): 29. - Thymoquinone from Nigella sativa exhibited antibacterial effects and promoted antimicrobial properties in vitro.
- Nikakhlagh S et al. Am J Otolaryngol. 2011. 32(5): 402-407. doi: 10.1016/j.amjoto.2010.07.019 - A placebo-controlled study (n = 66) found that N. sativa should be considered for treating allergic rhinitis as a viable alternative to current medication.
- Datau EA et al. Acta Med Indones. 2010 Jul. 42(3). 130-134. - A double blind, randomized, placebo-controlled study with obese males (aged 30 – 45 years) found that there was a significant reduction in body weight, waist circumference, and systolic blood pressure in the treatment group. Nigella sativa was also found to possibly inhibit the decreasing of serum free testosterone.
- Namji A et al. Int J Diab Dev Ctries. 2008 Jan-Mar. 28(1): 11-14. doi: 10.4103/0973-3930.41980 - A prospective study testing the effect of N. sativa oil as an add-on therapy in patients of insulin resistance syndrome. Indeed, the oil was found to have significant improvement in total cholesterol, low density lipoprotein cholesterol, and fasting blood glucose.
- Amin B et al. Planta Med. 2016 Jan. 82(1-2): 8-16. EPub 2015 Sep 14. doi: 10.1055/s-0035-1557838 - A review going into detail on all the properties of black cumin and thymoquinone; mainly focused on antinociceptive and anti-inflammatory effects.
- Darakhshan S et al. Pharmacol Res. 2015. 95(96): 138-158. doi: 10.1016/j.phrs.2015.03.011 - A review focused specifically on the actions of thymoquinone, the active constituent of Nigella sativa. The pharmacological actions of thymoquinone include, but are not limited to, antioxidant, anti-inflammatory, immunomodulatory, and anti-microbial.