- Liu W et al. Food Funct. 2014 Sep 11. 5: 2996-3004. DOI: 10.1039/c4fo00538d - Pomella® phenolics inhibit the formation of a biologically relevant oxidative stress marker called Advanced Glycation Endproducts, or AGEs.
Henning SM et al. J Agric Food Chem. 2014 Apr 18. 62: 4313-4321. DOI: 10.1021/jf500106r - Pomella® ranked highest in antioxidant activity across a number of assays including ORAC, TEAC, FRAP, and DPPH, compared to 26 other antioxidant products.
Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem. 2008 Feb 27. 54(4): 1415-1422. EPub 2008 Jan 26.
- Heber D et al. Safety and antioxidant activity of a pomeganate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007 Sep 21. 55(24): 10050-10054. EPub 2007 Oct 30.
- Seeram NP et al. Pomegranate juice extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food. 2008 Jan 23. 11(2): 390-394. DOI: 10.1089/jmf.2007.650
Mertens-Talcott SU et al. J Agric Food Chem. 2006 Sep 6. 54(23): 8956-8961. EPub 2006 Oct 13. DOI: 10.1021/jf061674h - Pomella’s patented extraction process delivers an ellagitannin rich profile standardized to punicalagin content. A single dose of Pomella led to a significant 32% increase of antioxidant activity in the blood. Bioactive punicalagin derived metabolites were detected in half an hour after dosing.
Seeram NP et al. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr. 2006 Jul 10. 136: 2481-2485.
Seeram NP et al. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from promegranate (Punica granatum L) juice. Clinica Chimica Acta. 2004 Apr 30. 348: 63-68. DOI: 10.1016/j.cccn.2004.04.029
Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr. 2003 Jan. 42(1): 18-28.
- Cai A et al. FASEB J. 2018 Apr. 32(1): 656.35.
Liu W et al. University of Rhode Island. Neurochem Int. 29 Sep 2016. 100: 164-177. - As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.
Goyal R et al. Int J Adv Res. 2016 May. Vol 4(Issue 5): 857-864. DOI: 10.21474/IJAR01 - Patients were administered 300mg of Pomella® twice daily for 30-days as an adjunct treatment and showed significant improvements in key metabolic biomarkers. Especially significant decreases in blood glucose and HbA1c were seen compared to baseline.
Goyal R et al. Eur J Biomed Pharma Sci. 2016 Apr 30. Vol 3(Issue 5): 662-667. - Patients were administered 300mg of Pomella® twice daily for 30-days as an adjunct treatment and showed significant improvements in biomedical parameters such as HDL, OX-LDL, serum homocysteine, hs-CRP, and others.
Yuan T et al. ACS Chem Neurosci. 2015 Nov 11. DOI: 10.1021/acschemneuro.5b00260 - Urolithins, gut microbial metabolites of ellagitannins, fulfilled in silico criteria required for BBB permeability, and prevented β-amyloid fibrillation in vivo. Moreover, urolithins not only prevented β-amyloid fibrillation in vitro, they also protected Caenorhabditis elegans from amyloid β1−42 induced neurotoxicity and paralysis, supporting Pomella's neuroprotective effect.
Ahmed AH et al. Current Alz Res. 2014. 11(9). - Pomella® was shown to impact cognitive function and markers of healthy brain aging in an aged transgenic AD model. Findings support a specific anti-amyloidgenic mechanism of Pomella.
Jean-Giles D et al. Chem-Bio Inter. 2013 Jun 20. 205: 90-99. EPub 2013 Jul 2. DOI: 10.1016/j.cbi.2013.06.018 - Pomella’s punicalagins were shown to inhibit collagen degradation and supported anti-inflammatory effects; indicating possible joint health support opportunities.
DiSilvestro RA et al. Phytother Res. 2009. 23: 1123-1127. EPub 2009 Jan 23. DOI: 10.1002/ptr.2759 - Pomella® mouthwash administered 3x daily affected saliva readings for antioxidant, anti-inflammatory, antibacterial, and bacterial enzyme inhibition compared to placebo. Further, Pomella reduced total protein count, which is associated with plaque forming bacteria.
Pacheco-Palencia LA et al. J Agric Food Chem. 2008 Jul 18. EPub 2008 Aug 22. DOI: 10.1021/jf8005307 - Pomella® was shown to be effective at protecting human skin fibroblasts from cell death following UVA and UVB exposure, while increasing the intracellular antioxidant capacity, and reducing the generation of intracellular reactive oxygen species (ROS) after UV exposure.
Patel C et al. Food Chem Toxicol. 2008 Apr 24. 46: 2728-2735. DOI: 10.1016/j.fct.2008.04.035 - Results of this trial indicated that the no observed adverse effect level (NOAEL) at the highest tested level of Pomella®, was 600 mg/kg body weight/day.
Shiner M et al. Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic antioxidants via PPAR gamma and AP-1 pathway activation. Atherosclerosis. 2007 Dec. 195(2): 313-321. EPub 2007 Feb 12.
deNigris F et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide. 2007 Aug. 17(1): 50-54. EPub 2007 May 5.
Pomegranates for the prostate and the heart: Seeds of hope. Harv Med Health Watch. 2007 Apr. 11(9): 4-5. No Abstract Available.
deNigris F et al. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res. 2007 Jan 15. 73(2): 414-423.
Aviram M et al. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001. 158: 195-198.
- Liu Y et al. J Sep Sci. 2018 May 30. Vol 41(Issue 15 - August 2018): 3022-3033. DOI: 10.1002/jssc.201800480 - Pomella® phenolics are comprehensively characterized by a validated liquid chromatography with time-of -flight tandem mass spectrometry method in the highly regarded journal, Journal of Separation Science. This study aids in quality control, authentication of study materials, and standardization of these botanical ingredients to help evaluate their potential health benefits in both completed and on-going pre-clinical and clinical studies.