These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Please note that the physiological activity of the ingredient(s) described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient(s) described herein are responsible for determining whether claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.


  • Ma H et al. Protective effects of a red maple (Acer rubrum) leaves extract on human  keratinocytes against H2O2-induced oxidative stress. FASEB J. 2018 Apr 20. Vol 32(No 1_supplement): 656-33. Poster Presentation at Experimental Biology 2018 Meeting.

  • Ma H et al. Cosmetic applications of glucitol-core containing gallotannins from a  proprietary phenolic-enriched red maple (Acer rubrum) leaves  extract: Inhibition of melanogenesis via down-regulation of tyrosinase  and melanogenic gene expression in B16F10 melanoma cells. Archives Dermatol Res. 2017 May. 309.4 (4): 265-274. EPub 2017 Mar 10. doi: 10.1007/s00403-017-1728-1 - GCGs show anti-tyrosinase activity via tyrosinase inhibition, reduce melanin content in melanoma cells, reduce the level of reactive oxygen species, down-regulate the tyrosinase-related gene (MITF, TYR, TRP-1, and TRP-2), and down-regulate protein expression (TRP-2 gene). The combined mechanistic attributes have been shown to elicit skin lightening/brightening effects.

  • Ma H et al. Glucitol-core containing gallotannins inhibit the formation of advanced  glycation end-products mediated by their antioxidant potential.  Food Funct. 2016 May 18. 7(5): 2213-2222. doi: 10.1039/c6fo00169f Maplifa’s GCGs showed superior activities compared to the synthetic anti-glycating agent, aminoguanidine, at the early, middle, and late stages of glycation; in short, exhibiting protective effects against glycation-induced skin aging and promoting healthy skin aging. GCGs have free radical scavenging activities. Maplifa™ reduces HO-induced oxidative stress in human keratinocytes (HaCaT) cells.

  • Unpublished Data. Manuscript under publication. - GCGs inhibit elastase enzyme activity, which improves & boosts the skin’s elasticity for dermal support and a youthful appearance.