Yu Y et al. Sci Rep. 2013 Nov 05. 3(3142): 1-8. - A murine model examining Factor 21™ showed significant reductions in body weight, fasting plasma glucose, insulin, and FGF21 concentration as well as liver FGF21 and TG content in mice fed a high fat diet. Researchers pose that Factor 21™ supplementation may contribute to either increased energy, reduced caloric absorption from the gut, or a combination of both.
- Unpublished internal report. - An in vitro examination of the effects of varying concentrations of Factor 21 on AMPK activity in 3t3-L1 adipocytes compared to AICAR (Acadesine/AICA ribose, a cell permeable activator of AMP-activated protein kinase (AMPK). Results indicated a dose-dependent induction of pAMPK up to 250ug/mL. The bell shaped results were indicative of come receptor induced activation.
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