- Dhatrak S et al. Effect of herbal combination in low bone mass density patients. Int J Drug Discov Technol. 2011. 2(1): 9-14. - In this double blind, randomized, placebo control trial in women (45-60 years old) with low BMD identified by DEXA scan (n=30), supplementation of an herbal combination containing Calzbone® showed significant improvement in bone density parameters namely BMD, T score, and Z score, while also showing a reduction in serum total ALP activity (most commonly used biochemical markers to assess bone turnover (formation and resorption)) in the active treatment group compared to placebo. During the six-month period of this study, BMD was found to increase by 2.74 % in the Calzbone® group.
Goswami SS et al. Efficacy of Cissus quadrangularis [Calzbone®] in perimenopausal low bone density women. Antiseptic. 2011. 108(10): 504-6. - This study was done to evaluate efficacy and safety of Calzbone® in perimenopausal low bone mass density (BMD) women, identified by DEXA scan (45-55 years old, n=40), at the dose of one capsule three times a day for six months. A significant improvement in bone density parameters, BMD, T score, and Z score with a 17% improvement in bone density was reported at the conclusion of the study, indicating a decreased future fracture risk. Serum total ALP activity was found to decrease significantly at the end of the study compared to baseline. Calzbone® was well tolerated.
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