Merriam-Webster defines transdermal as relating to, being, or supplying a substance in a form for absorption through the skin into the blood stream. 1 Botanical supplements are able to offer formula flexibility for application diversity, which can include oral and topical activity. For example, it may increase the concentration of those actives to the part of the body where it is most desired, such as the skin, as well as for a particular joint as in the case of a potent natural mediator of inflammatory cytokines. It is an often-forgotten fact that the skin is the largest organ in the human body, and thus provides a unique delivery method for bioactive extracts, such as those found in Boswellia serrata.2